憂鬱症與基因


在與憂鬱症相關的基因表達調控區域存在一個常見的基因變異,即長型基因(L)或是短型基因(S),具有一個或兩個S基因型者的神經質指數較LL型者高。然而,S型者不會先天性地造成憂鬱症的產生,但是具有此基因型者對於負面情緒因子的反應較強烈,影響的時間也較久,因此在先天上的抗壓能力較差,所以在遇到壓力事件驟增時,造成憂鬱症機率就較LL者要高出許多。

  

臨床上憂鬱症的治療方式不外乎藥物治療及心理諮商治療,藉由身體狀況的調整以及紓壓減壓等自我情緒照顧能力的提升,來提升個人的生活品質並減少憂鬱症可能的影響。在了解了您先天上基因的特質後,以下事項是為協助維護您的健康可以做的:

 

1.   每天定時做30分鐘運動

2. 早餐進食適量的蛋白質:

花生,燕麥,香蕉,青豆,牛肉,羊肉,牛肉湯,瑞士乳酪,杏仁,牛奶,小牛肝,烤火雞,義大利乾酪,蛋黃,雞蛋面等食物之攝取有助於合成神經遞質血清素。

3.   如果你自覺是個較敏感的人,戒咖啡因(濃茶/咖啡)

4.   每天食3種不同的水果及至少2種蔬菜

5.   壓力大時每天更要多飲白開水

6.   晚餐進食適量的碳水化合物 (飯、麵、粥、粉等)

7.  每天定時做30分鐘進行自我放鬆與覺察的練習

8.  凡事盡力而為,量力而為

9.   與別人分享自己的感受

10. 每週抽空3小時做一樣滿足自己興趣的活動

11.  盡量保持正常的作息

12.  必要時尋求醫療的協助:心理諮商治療或藥物處方協助

 

林醫師的話:

基因型為SS型比起LL或是SL型基因更常見於憂鬱症的病人身上,但是不代表基因型一定會產生憂鬱症,臨床上還是以美國精神醫學會診斷標準DSM IV和精神科醫師門診診斷為主。基因型可以讓醫師去預測未來跟病患的治療與預後當個參考。

2 thoughts on “憂鬱症與基因

  1. Dear Dr. Lin,
    It’s my first time to visit this website. I’m glad to know you. I had taken medicine for 9 years more. I’ve a quetion. Shouldn’t a major depression take medicine for so long time? While the situation becomes stable, shouldn’t have a chance not to take it? unwanna take so long time and even for “eternal" life. My doctor said that I’m the “model patient, " but that’s not my want. Can’t be controlled by medicine but me or other ways? Thx a lot.

    ps. it’s ok reply in Chinese, coz i just want to keep my privacy on the public website. thx a lot.

    • Hi Roni,

      it is clear that nobody would be delighted to take the medicine even needed. Taking drugs more than 9 years is actually beyond my imagination. Diseaes like schizophrenia and biploar disoder do need life long medication. Major depression however took a “flunctuation" course in some patients , someone like you. U can took prophylaxis dosage or “wait" to see . There is NO evidence revealing that patient with major depression should be taking the drugs that long. Try to discuss with ur doc. Summer is a good chance to be “off" the drug under ur doc’s instruction. taking exercise and more fish might help.
      Good Luck

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